layiq

/la·yiq/adjective

worthy; deserving; fitting; suitable.

A role, opportunity, or path that merits attention, time, and pursuit.

Executive Director / Vice President, Biology & Translational Pharmacology at Profluent | LAYIQ

Build and oversee a high-performing liver biology and translational pharmacology organization, including direct management of program and in vivo pharmacology leaders
Lead scientific strategy and execution for 2–3 liver-directed genetic medicine programs, translating Profluent’s customized base editor platform into a differentiated portfolio for severe inborn metabolic diseases
Provide accountable leadership for cross-functional therapeutic program teams, integrating translational biology, genome editing, protein engineering, delivery, pharmacology, bioanalytics, CMC, regulatory, and preclinical development expertise
Partner with functional leaders to define program resourcing, critical-path activities, timelines, risks, and key experiments required to deliver development candidates and IND-ready data packages
Guide in vivo pharmacology strategy across rodent and NHP studies, including model selection, dose strategy, biodistribution, editing activity, durability, target engagement, pharmacodynamic biomarkers, tolerability, and translational relevance
Bring deep liver and metabolic disease expertise to the design of experiments that distinguish mechanism, causality, pharmacology, and therapeutic impact across genetically defined disease contexts
Apply strong scientific judgment to experimental design, data interpretation, and program decision-making, ensuring studies are efficient, well-controlled, and capable of supporting clear go/no-go decisions
Translate Profluent’s established liver portfolio vision into actionable program strategy for selected targets, while contributing to future prioritization of additional genetically defined opportunities in liver and other tissues
Represent program strategy, data, risks, and recommendations to executive leadership, board members, external advisors, potential partners, investors, and collaborators
Cultivate a collaborative, execution-oriented culture that moves quickly while maintaining scientific rigor, thoughtful prioritization, and high standards for data quality

PhD, MD, DVM, PharmD, or equivalent advanced degree in pharmacology, molecular biology, genetics, physiology, hepatology, bioengineering, medicine, or a related discipline
PhD in related discipline with significant (12+ years) biopharma R&D experience, with a strong track record in genetic medicines, liver biology, translational pharmacology, and preclinical development
Demonstrated track record advancing multiple therapeutic programs from concept through development candidate nomination; experience advancing at least one program into IND-enabling studies or clinical development is strongly preferred
Deep experience with genetic medicines or advanced therapeutic modalities, such as RNAi, antisense oligonucleotides, mRNA/LNP therapeutics, gene therapy, genome editing, or related platforms
Deep understanding of liver biology and metabolic disease, with the ability to connect human genetics, disease biology, pharmacology, biomarkers, translational models, and development strategy
Extensive experience with rare liver diseases, lipid biology, hepatology, fibrosis biology, and / or metabolic liver disease
Experience designing and interpreting in vivo pharmacology studies, including rodent and/or NHP studies evaluating PK/PD, biodistribution, dose response, target engagement, pharmacodynamic biomarkers, durability, efficacy, and tolerability
Demonstrated ability to lead multidisciplinary scientific teams, including direct management of senior scientists or functional leaders and leadership of matrixed drug-discovery project teams
Working knowledge of IND-enabling requirements, toxicology interfaces, CMC considerations, bioanalytical assay needs, and regulatory expectations sufficient to guide program-level decisions
Outstanding written and verbal communication skills, with the ability to tailor scientific and strategic messages for audiences ranging from technical project teams to senior executives, board members, external advisors, partners, and generalist investors
Direct experience or at least high-level familiarity with gene editing proteins such as nucleases, base editors, prime editors, recombinases, etc
Team-centered and deeply collaborative, with a positive presence that motivates others; inspired by the opportunity to translate great science into meaningful outcomes for patients

Executive Director / Vice President, Biology & Translational Pharmacology

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