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Output Biosciences
New York, United States; San Francisco, California, United States
Source: Output Biosciences careers · View original posting
From Output Biosciences's posting. “We” and “our” refer to the employer.
Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one.
Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.
You will lead the design and development of Output's generative models, working across molecular modalities to build systems that produce novel, biologically grounded molecules. This role spans the full arc from research to trained model: you design architectures, develop training approaches, run experiments on distributed GPU clusters, and evaluate results.
You will design and build generative architectures for molecular data spanning multiple modalities, including small molecules, peptides, mini proteins and more
You will develop training approaches that learn from diverse biological signal, ensuring the model composes genuinely novel structures
You will build methods for controllable, targeted generation, enabling the model to produce molecules with specified biological properties while satisfying real-world chemical constraints
You have a PhD in computer science, machine learning, physics, mathematics, or a related field with 2+ years of post-doctoral or industry research experience, or a Bachelor's or Master's degree with 5+ years of hands-on research and engineering experience in generative modeling
Bonus Points
You have experience applying generative models to molecular, chemical, or biological data
You have a background in chemistry, biology, computational biology, biophysics, or a related natural science
We encourage new and different ideas, creativity and contrarian thinking
Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you
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