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Convergent Research
Alameda, California
Source: Convergent Research careers · View original posting
From Convergent Research's posting. “We” and “our” refer to the employer.
E11 Bio is on a mission to advance connectomics towards whole brain scale for humans and other mammals. We are a collaborative and interdisciplinary team of scientists and engineers engaged in a neuroscience moonshot project to develop a radical technology platform for scalable mammalian brain mapping. E11 Bio is a non-profit Convergent Research focused research organization located in Alameda, California, pursuing blue-skies neuroscience research yet operating like a nimble, tight-knit start-up. Read our technology roadmap.
E11 Bio is seeking a mission-aligned experimental scientist, equally at home at the bench, the microscope, and in quantitative data analysis, who brings an engineering approach to the full pipeline, from sample preparation through molecular readout tools and microscopy. This role involves both optimizing the physical preparation of the tissue and implementing agentic microscopy.
Reporting to the Barcoding Lead, you will define what high-quality tissue means quantitatively and will drive the improvement of high quality morphology and protein readout by working closely with molecular biology, imaging, and computational teams to support whole-brain connectomics.
In collaboration with external and internal partners, extend agentic control beyond acquisition to the everyday steps of the sample pipeline (e.g. liquid handling, staining, gelation, and intermediate readouts)
80% of samples entering gelation at E11 meet or exceed our sample quality threshold (rolling average)
If tissue artifacts affect segmentation, 80% of samples entering gelation at E11 meet or exceed our tissue quality threshold (rolling average)
Incorporated protein retention, antigenicity, and specificity as per-stage metrics across the sample generation pipeline and demonstrated their predictive power for key downstream outcomes (e.g. segmentability)
Agentic control and fault detection running across parallelized microscopes with measured increase in unattended acquisition time without loss of quality
Identified and validated multiple cocktails of binders for stratifying excitatory and inhibitory synapses
E11 Bio, LLC is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other basis protected by applicable local, state, or federal laws or prohibited by Company policy.
We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.
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