Executive Director, Scientific & Medical Excellence

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way.

We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.

Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You'll Do

• The Executive Director, Scientific & Medical Excellence is a senior leadership role within Medical Affairs, accountable for the cross-cutting scientific capabilities and programs that serve BridgeBio’s portfolio. This leader will own evidence generation planning, the investigator-sponsored trial (IST) and sponsored research portfolio, Medical Information, expanded access / compassionate use programs, and the integration of artificial intelligence into Medical Affairs ways of working—while driving global planning and alignment across affiliates and functions.
• This individual will build and scale the operating model, governance, and standards that allow Medical Affairs to act with scientific rigor, speed, and compliance. The role requires deep expertise in rare disease, the maturity to lead in a matrixed, fast-paced environment, and the vision to modernize how a medical organization generates and exchanges scientific evidence. The role partners closely with Clinical Development, Regulatory, Commercial, Market Access, HEOR, Patient Advocacy, and Field Medical.

Responsibilities

• Evidence Generation Planning
• Lead the development of the integrated evidence generation plan, in partnership with HEOR, aligned to overarching medical and asset strategy and informed by clearly prioritized scientific and stakeholder evidence gaps.
• Coordinate the planning of real-world evidence (RWE), registries, natural history studies, database analyses, and Phase 4 / post-marketing studies in partnership with Clinical Development, HEOR, and Biostatistics.
• Ensure evidence plans support regulatory interactions, value demonstration, payer engagement, and HTA requirements, and that data are disseminated through a coordinated publication strategy.
• Investigator-Sponsored Trials (IST) & Sponsored Research Partnerships
• Own the strategy, governance, and end-to-end operations of the investigator-sponsored trial (IST) program, including the review committee, scientific prioritization, and funding decisions aligned to medical strategy and evidence gaps.
• Develop and manage sponsored research collaborations and external research partnerships with academic centers, consortia, and cooperative groups.
• Establish transparent processes for proposal intake, contracting, milestone tracking, publication expectations, and compliant oversight of supported research.
• Partner with Legal, Compliance, Finance, and Regulatory to ensure all externally sponsored research meets internal standards and applicable regulations.
• Medical Information
• In partnership with the Bridge Bio MI Lead, manage affiliate Medical Information function, including strategy, content, and operations for responding to unsolicited requests from healthcare professionals, patients, and other stakeholders.
• Oversee development and scientific governance of standard response documents, FAQs, and the medical information content library, ensuring accuracy, balance, and compliance.
• In partnership with Central Med Info, manage call center / vendor operations, escalation pathways, and service-level standards for medical inquiry handling.
• Expanded Access / Compassionate Use Programs
• Develop, implement, and manage expanded access / compassionate use (early access, named-patient, and managed access) programs in alignment with medical, regulatory, and ethical standards.
• Establish governance, eligibility criteria, request-handling workflows, and supply coordination, balancing patient need with program integrity and compliance.
• Partner with Regulatory, Clinical, Supply Chain, Legal, and Patient Advocacy across regions to ensure consistent, equitable, and compliant access processes.
• Technology & Innovation in Medical Affairs
• Define and drive the Medical Affairs AI strategy—identifying, piloting, and scaling AI and advanced analytics use cases across medical information, evidence synthesis, content generation, insights, and operations.
• Partner with Data Science, IT, Legal, and Compliance to establish responsible-use, governance, validation, and data-privacy guardrails for AI tools in a regulated environment.

This is a U.S.-based remote role that will require periodic, or as-needed, visits to our San Francisco office, plus travel for conferences, partner meetings, and global alignment (approximately 20% of time).

Who You Are

MD, DO, PharmD, PhD, or equivalent advanced scientific or clinical degree.

12+ years of experience in Medical Affairs, including leadership roles, within the biopharmaceutical industry and/or academic medicine.

Demonstrated, hands-on leadership experience across several of the core areas of this role: Medical Information, investigator-sponsored / sponsored research programs, evidence generation planning, and expanded access / compassionate use programs.

Experience driving AI, digital, or advanced-analytics initiatives within Medical Affairs strongly preferred.

Experience leading global or multi-region medical planning and alignment in a matrixed organization.

Demonstrated experience in rare disease strongly preferred.

Strong understanding of regulatory and compliance requirements related to medical information, externally sponsored research, expanded access, and post-marketing activities.

Strategic thinker with strong execution capabilities and a track record of building scalable processes, governance, and teams.

Excellent written and verbal communication skills, including experience presenting to senior leadership and external stakeholders.

High degree of scientific rigor, integrity, and patient-centered focus.

At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California.

The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.

Skill Development & Career Paths:

People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility

We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching

We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities