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Washington University in St Louis
Washington University Medical Campus; Steven & Susan Lipstein BJC Institute of Health
Source: Washington University in St Louis careers · View original posting
From Washington University in St Louis's posting. “We” and “our” refer to the employer.
Location
SAINT LOUIS, MO 63110

 Scheduled Hours
40
Position Summary
The Sah laboratory at WashU Medicine in St. Louis (Department of Internal Medicine, Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) studies the mechanisms of Transient Receptor Potential (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction.
The laboratory uses electrophysiological (e.g., patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, and endothelium and pancreatic islet cells.
Broadly speaking, the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism. We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.
Job Description
A laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment, provide standard care to research animals, and handle human biosamples.
Compensation
Base pay is commensurate with experience.
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.
Required Qualifications
Bachelor’s degree or combination of education and/or experience may substitute for minimum education.
No specific certification/professional license is required for this position.
No specific work experience is required for this position.
Not Applicable
A driver's license is not required for this position.
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