Postdoctoral Research Associate - Hematology

The Cheng Laboratory at St. Jude Children’s Research Hospital is seeking a highly motivated Postdoctoral Research Associate with expertise in bioinformatics, computational genomics, and machine learning to develop computational approaches at the intersection of functional genomics, genome engineering, and therapeutic development.

Our laboratory integrates computational and functional genomic approaches to understand genetic variation and develop new strategies for precision medicine. The successful candidate will work in a highly collaborative environment combining large-scale genomic data, functional genomic screening, genome editing, machine learning, and experimental validation.

A major component of this position will contribute to an ARPA-H–supported program focused on developing personalized genome-editing therapies for rare diseases. The program includes development of AI models for predicting biochemical and cellular genome-editing activity and off-target effects, with experimental data used for model training and prospective validation.