layiq

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Postdoctoral Research Associate - Structural Biology – Scott Blanchard Lab at St. Jude | LAYIQ

· Lead the experimental design, execution, and data analysis of biophysical studies characterizing GPCR structural dynamics with in vivo downstream signaling response.
· Engineer and isolate high-quality, homogeneous samples of GPCRs and signaling partners for ensemble and single-molecule analytical assays.
· Expand your technical skillset through expert-led training in smFRET imaging to perform experiments, analyze complex datasets, and develop quantitative models to explain GPCR signaling mechanisms.
· Work independently, leading a project from hypothesis to high-quality oral presentations and publications.
· Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience.
· Train and mentor graduate students, postdocs and visiting scientists.
· Instruct other staff in basic laboratory techniques and procedures.
Minimum education: · Ph.D in life science or other physical science.
Minimum Experience: · 0-3 years of Post-PhD experience.
· Prior experience in GPCR signaling studies and/or single-molecule fluorescence analyses is highly preferred.
· Direct experience with isolation and functional characterization of GPCRs and their signaling partners (G-proteins, arrestins, GPCR kinases, etc.) is strongly preferred.
Selected Publications: Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale .
Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function.
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision .
Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.
Single-molecule FRET imaging of GPCR dimers in living cells
Quantifying secondary transport at single-molecule resolution
CFTR function, pathology and pharmacology at single-molecule resolution
St. Jude is an Equal Opportunity Employer
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Postdoctoral Research Associate - Structural Biology – Scott Blanchard Lab

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