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Xenon Pharmaceuticals
Needham, Massachusetts, United States
Source: Xenon Pharmaceuticals careers · View original posting
From Xenon Pharmaceuticals's posting. “We” and “our” refer to the employer.
Xenon Pharmaceuticals (
NASDAQ:XENE
) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications.
In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication.
We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting.
We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
We are seeking an Associate Director, CMC, Drug Substance to join our CMC Drug Substance team. The candidate will help manage and oversee the development and manufacturing of cGMP small molecule active pharmaceutical ingredients (APIs) for deployment in pre-pivotal and pivotal clinical trials. The Associate Director will be a key member of a highly collaborative internal CMC team, primarily managing API development programs and manufacturing campaigns through contract development and manufacturing organizations (CDMOs).
This position reports to the Senior Director, CMC, Drug Substance, and will be based out of Boston, MA, USA. We will consider remote locations for exceptional candidates.
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