From Nurix Therapeutics's posting. “We” and “our” refer to the employer.
Director, Drug Safety
Join Nurix’s pharmacovigilance team to help ensure patient safety across our clinical pipeline of targeted protein degradation therapies. As Director, Drug Safety, you’ll lead aggregate safety analysis, benefit–risk assessments, and safety strategy for assigned programs — shaping how we evaluate risk and bring new medicines safely to patients. It’s a chance to influence critical safety decisions at the intersection of clinical medicine, data, and drug development.
The Opportunity
Medical Safety Leadership
Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities
Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization
Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments
Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication
Regulatory and Safety Documentation
Oversee medical review of Individual Case Safety Reports (ICSRs)
Author and review regulatory safety documents, including Development Safety Update Reports (DSURs) and safety sections of INDs and regulatory briefing books
Contribute to safety responses to regulatory authorities and participate in regulatory interactions
Provide clinical leadership during inspections and audits related to safety and risk management
Clinical Development Support
Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures
Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy
Governance and Cross-Functional Collaboration
Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation
What You’ll Bring
Advanced clinical or scientific degree, such as MD, DO, PharmD, or equivalent relevant training and experience
Clinical experience preferred
5–10 years of experience in pharmacovigilance/drug safety within the pharmaceutical or biotechnology industry
Experience supporting early clinical development and small biotechnology companies
Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation
Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA)
Experience interacting with global health authorities on safety matters
Familiarity with signal detection and safety surveillance tools and databases
Strong communication, collaboration, and cross-functional leadership skills
Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy
Ability to work effectively and collaboratively in a fast-paced, growing organization across functional boundaries
The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location:
Onsite – Brisbane, CA
Fit with Nurix Culture and Values
Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases.
Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
About this listing
LAYIQ is an independent job-discovery service. This listing does not imply a partnership with or endorsement by the employer. Review the original posting for current details and availability.
