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HAYA Therapeutics
San Diego, CA, US
Source: HAYA Therapeutics careers · View original posting
From HAYA Therapeutics's posting. “We” and “our” refer to the employer.
At HAYA Therapeutics, we are pioneering a new class of programmable RNA-guided therapeutics that target the regulatory genome to reprogram disease-driving cell states. By decoding the causal biology of pathological cell states and the long-noncoding RNAs (lncRNAs) that regulate them, HAYA translates these insights into tractable therapeutic candidates designed to address disease at its source and restore cellular health. HAYA is advancing a broad pipeline of RNA-guided medicines for chronic, age-related diseases.
Recognized globally for our scientific innovation, HAYA has been named a 2025 Technology Pioneer by the World Economic Forum (WEF), selected for BioSpace's NextGen Bio Class of 2026, recognized as a 2026 Disruptive Pioneer by IDEA Pharma, and celebrated as one of the Top Innovative Companies in Switzerland for 2025. As a fast-growing biotech, we offer an entrepreneurial, science-driven environment where you’ll have a direct impact on shaping our pipeline and advancing RNA medicine
1. Purpose:
Execute preclinical cellular assays, tissue histology, nucleic acid extractions, and spatial transcriptomics protocols to generate high-quality experimental data supporting HAYA's functional genomics and lncRNA target validation pipelines.
2. Accountabilities
Primary Cell Culture & ASO Screening Execution
·Execute primary cell isolation, tissue culture, and cell line maintenance (including human and mouse fibroblasts, C2C12 cells, myoblasts, and satellite cells) to establish robust in vitro disease models.
Perform compound treatments and antisense oligonucleotide (ASO) screening protocols (including GapmeRs and siRNA) across primary cell platforms to evaluate target knocking-down efficiency and therapeutic potency.
Isolate and process RNA, DNA, and proteins from cellular and tissue specimens using standardized extraction techniques to prepare high-integrity samples for downstream molecular profiling.
Tissue Histology & Spatial Transcriptomics
Perform tissue processing, FFPE embedding, sectioning, and staining protocols (including immunohistochemistry and immunofluorescence) to quantify fibrotic markers and evaluate tissue morphology.
Execute spatial transcriptomics and multi-omics assay workflows in alignment with functional genomics protocols to characterize spatial gene expression in target tissues.
Capture and analyze fluorescence microscopy images across immunostained and spatial transcriptomic tissue sections to extract qualitative and quantitative cellular insights.
Preclinical Model Support & Data Governance
Support in vivo preclinical study workflows by assisting with tissue dissections and sample collection from skeletal mouse and disease models to supply downstream experimental workstreams.
Maintain detailed, real-time Electronic Lab Notebook (ELN) records, SOPs, and experimental documentation to ensure absolute data traceability, reproducibility, and audit readiness.
Synthesize, analyze, and present experimental dataset summaries to internal R&D project teams and scientific leadership to inform ongoing pipeline decision-making.
Salary Range: $70,000 to $90,000
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