Sr/Exec Director GI Medical Strategy

Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide.

The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Position Summary:

Reporting to the VP of Medical Affairs, the Senior or Executive Director, GI Medical Strategy will drive the overarching medical strategy and execution for GI cancers with a focus toward pancreas cancer. This person will work closely with cross-functional teams in the development, management, and execution of the clinical development plan, evidence generation strategy, scientific narrative, and KOL engagement strategy.

The Senior or Executive Director, GI Medical Strategy will serve as a GI cancers subject matter expert and key thought partner, both internally and externally, and will have individual responsibility for growing and developing the medical affairs function within GI cancers at the company.

Note that this position can be hybrid in San Diego, CA or South San Francisco, CA or fully remote anywhere in the United States.

Essential Duties and Responsibilities:

Strategic and tactical lead for GI cancers in Medical Affairs. Coordinates across all Medical Affairs, R&D, and other functions by developing and maintaining strategic plans and budgets.

Partners across internal stakeholders in the development of the GI cancers overall medical strategy, clinical development plan, evidence generation strategy, scientific narrative, and KOL engagement strategy.

Collaborates and drives GI cancers tactical planning. Manages execution of Medical Affairs activities including publication development, insight generation initiatives, medical communications, evidence generation, training, and early access.

Serves as a subject matter expert in gastrointestinal oncology with an emphasis on precision therapeutics in pancreas cancer. Assimilates emerging information into existing disease state and competitive context.

Develops and manages strategic relationships with GI oncology thought leaders.

Facilitates relationships with external societies, advocacy groups, and alliance partner engagements.

Leads Medical Affairs GI oncology research studies including phase 4 company sponsored research, registries, investigator sponsored research, collaborative trials, meta- analyses

, and retrospective studies. Provides scientific expertise on study design, rationale, and alignment to strategy.

Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations.

Required Education and Experience:

Advanced degree (MD, PhD, PharmD) in a medical or science specialty preferred, significant experience in the medical field may be considered in lieu of an advanced degree

8

• + years of related experience at a pharmaceutical company in medical affairs or clinical development role
• Significant understanding and experience in GI cancers required
• ; including evolving disease, treatment, and thought leader landscapes

Strong scientific acumen required to communicate with key internal and external stakeholders.

• Firm understanding of the strategy and processes that are involved in both the non-clinical and clinical aspects of drug development
• Strong and timely communication skills, both oral and written, and capability to build trust and respect of partners
• Leads with influence, vision, and positive intent; culture builder
• Agility and flexibility in working across diverse therapeutic areas in a fast-paced growth stage biotech company
• Proven track record of timely decision making, prioritization, and a solution-oriented mindset in successfully addressing objectives

Demonstrated ability to achieve high performance goals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability to identify and implement creative solutions to complex problems.

Experience managing budgets and vendor partnerships

Demonstrated understanding of legal and compliance environment of pharmaceutical industry.

• Strong learning orientation, curiosity, and commitment to science and patients
• 20-35% domestic and international travel required to attend key internal and external professional meetings
• The anticipated