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Washington University in St Louis
Washington University Medical Campus; 4444 Forest Park Ave.
Source: Washington University in St Louis careers · View original posting
From Washington University in St Louis's posting. “We” and “our” refer to the employer.
Location
ST. LOUIS, MO 63108

 Scheduled Hours
40
Position Summary
We are seeking a highly motivated scientist to join our functional genomics team at the Goldfarb Center for Neuronal Resiliency at the McDonnell Genome Institute, WashU Medicine. The Goldfarb Center for Neuronal Resiliency was established to identify new therapeutic targets and treatments for neurodegenerative diseases, particularly ALS and Parkinson’s disease.
Central to this effort are CRISPR screens that identify genes that make neurons more vulnerable or resilient to stress. These screens will use human induced pluripotent stem cell (iPSC)-derived neuronal models of neurodegenerative diseases. Work in the lab also integrates CRISPR perturbations with phenotypic assays and molecular readouts using flow cytometry, high content imaging, next-generation sequencing, and single-cell, spatial, and in situ profiling.
Led by Drs. Jeff Milbrandt and Rob Mitra, The Goldfarb Center for Neuronal Resiliency is a highly collaborative and interdisciplinary research environment integrating functional genomics, stem cell engineering, neuroscience, high throughput imaging, next-generational sequencing, artificial intelligence, and drug discovery. Our work is inspired by the observation that neurodegeneration is strikingly selective for specific neuronal populations. For example, in ALS, motor neurons degenerate while neighboring interneurons remain intact.
Even within motor neurons, some subtypes are highly vulnerable, while others are resilient. We believe these differences in resiliency provide clues to new therapeutic strategies that have yet to be harnessed for drug development. Specifically, our long-term goal is to discover therapeutics that activate resiliency factors or inhibit vulnerability factors in diseased neurons in order to restore them to heath and reverse the progression of these debilitating diseases.
Job Description
For more about this project, visit https://genome.wustl.edu/the-resiliency-project-advancing-neurodegenerative-disease-research-at-mgi/ .
Because some cell culture, differentiation, and time-sensitive experimental workflows require procedures on specific days, the successful candidate must be able to accommodate occasional weekend work when required by experimental schedules .
This position works in a laboratory environment with potential exposure to biological and chemical hazards.
The individual must be physically able to wear protective equipment.
Compensation
Base pay is commensurate with experience.
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.
Required Qualifications
Bachelor’s degree or combination of education and/or experience may substitute for minimum education.
No specific certification/professional license is required for this position.
No specific work experience is required for this position.
Not Applicable
A driver's license is not required for this position.
More About This Job
Compensation
Base pay is commensurate with experience.
The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.
Questions
For frequently asked questions about the application process, please refer to our External Applicant FAQ .
Accommodation
If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.
All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.
Pre-Employment Screening
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
LAYIQ is an independent job-discovery service. This listing does not imply a partnership with or endorsement by the employer. Review the original posting for current details and availability.
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