From Colossal Biosciences's posting. “We” and “our” refer to the employer.
An affiliate of Colossal is seeking an experienced Research Associate/Senior Research Associate to support precision genome engineering in non-model mammalian organisms. You will produce and validate CRISPR/Cas9, prime editing, base editing, and multiplex editing reagents that enable Cell Engineering colleagues to generate edited cell lines. We seek a technically proficient, hands-on contributor who can execute established workflows independently and contribute from the outset.
This position is based on-site in Dallas, TX. Relocation assistance is available.
Duties and Responsibilities:
Generate and quality-control genome editing reagents, including sgRNAs, pegRNAs, donor DNA templates, plasmids, and expression constructs
Perform molecular cloning, DNA assembly, bacterial culture, plasmid purification, PCR, and sequence verification
Support preparation and quality control of RNA reagents, including in vitro transcription and purification where applicable
Prepare and track reagent sets for multiplex genome editing experiments, maintaining accurate construct and sample identities
Work with Genome Engineering scientists to implement and troubleshoot CRISPR/Cas9, prime editing, and base editing designs
Transfer validated reagents and clear experimental documentation to Cell Engineering colleagues for transfection and downstream cellular workflows
Perform PCR-based genotyping, prepare samples for sequencing, and support analysis of single-locus and multiplex editing outcomes
Maintain accurate electronic laboratory records, reagent inventories, and quality-control documentation in ELN
Organize concurrent experiments, communicate results, and proactively improve workflows
Required Education, Skills, and Abilities:
BA/BS or MA/MS in molecular biology, genetics, biotechnology, bioengineering, or a related field
Demonstrated hands-on molecular biology research experience, including cloning, PCR, plasmid preparation, and sequence verification
Practical experience supporting CRISPR/Cas9 genome editing and multiplex editing experiments or reagent workflows
Experience preparing, handling, and quality-controlling DNA and/or RNA editing reagents
Ability to independently execute established protocols, troubleshoot routine technical problems, and contribute immediately with limited training
Strong organizational skills, attention to detail, and written and oral communication skills
Preferred Skills and Abilities:
Hands-on experience with prime editing and/or base editing reagents and workflows
Experience designing or preparing pegRNAs, modified guide RNAs, or HDR donors
Experience with in vitro transcription, RNA purification, or nucleic acid QC
Experience with sequencing-based genotyping and analysis of multiplex edits
Experience with electronic laboratory notebooks and cross-functional reagent handoffs
What Colossal Offers Full-Time Employees:
Medical, dental, and vision coverage
Excellent paid time off and company holidays so you can rest and recharge
Flexible spending accounts (FSA)
Company matched 401k retirement plan
Paid parental leave at 100% salary for up to 12 weeks
Education reimbursement
An opportunity to help us return the Earth to a healthier state
The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.
Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.
Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.
EEO is the Law
Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.
Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:
#1 on the 50 Best Startups to Work For in Dallas in 2023!
100 Best Midsize Places to Work in Dallas in 2024 & 2025
100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.
Built In 2026 Award Lists
Great Place to Work Certification Page
Most Loved Workplace Certification Page
Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.
Newsweek's Most Loved Workplaces 2024 Award List
Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!
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