Senior Manager, Program Management

MISSION

Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously.

POSITION SUMMARY

The Senior Program Manager, Drug Development will partner with the Program Lead and cross-functional Development Team to shape and execute integrated program strategy and long-range plans from preclinical development through regulatory approval and commercialization. This role will drive team alignment and disciplined execution across scope, schedule, risks and issues, budget, resources, governance, and stakeholder communications.

The Senior Program Manager will connect research, CMC, nonclinical, clinical, regulatory, and commercial functions to ensure clear goals, informed decisions, and coordinated delivery of key program milestones.

JOB FUNCTIONS/RESPONSIBILITIES

In this role, you will partner with Program Team Lead to lead integrated program planning and execution, enable effective cross-functional governance, and help teams anticipate and navigate key development decisions.

Support Program Lead and Development Team members to develop, maintain, and execute the cross-functional program strategy and integrated development plan.

Establish and maintain functionally integrated program schedules that enable accurate analysis of critical path activities, dependencies, milestones, and resource constraints.

Identify, assess, and track program risks and issues; facilitate mitigation and contingency planning and escalate material concerns through the appropriate governance channels.

Support Program Lead and Development Team members to develop scenario planning around key milestones and decision points, helping teams evaluate trade-offs, prepare alternative outcomes, and identify opportunities to accelerate development.

Connect short-, mid-, and long-term plans across functions and proactively highlight interdependencies, assumptions, and potential impacts to program objectives.

Partners with the program lead to facilitate cross-functional team and governance meetings, including agenda development, decision framing, documentation of outcomes, and follow-through actions.

Drive timely, transparent program reporting for stakeholders and leadership, including progress against milestones, key decisions, risks, resource needs, and team accomplishments.

Build strong relationships with functional partners and leaders across research, CMC, nonclinical, clinical development and operations, regulatory, and commercial teams.

Serve as a Program Management subject matter resource and contribute to the continued evolution of Program Management tools, processes, standards, and ways of working.

Contribute to Program Management department goals and initiatives; may provide coaching, mentorship, or oversight to other Program Management staff.

Perform other duties as assigned.

QUALIFICATIONS

• Education/Experience: BA/BS in a life sciences discipline with 5+ years of multidisciplinary pharmaceutical or biotechnology industry experience in program management; or a master’s or PhD degree with 4+ years of relevant experience.
• Experience supporting l drug development programs through key clinical and/or regulatory milestones demonstrating knowledge of the drug development process.
• Demonstrated understanding of program and project management practices, tools, and methodologies, including integrated planning, critical path analysis, risk management, scenario planning, and status reporting.
• Ability to facilitate cross-functional teams, manage conflict, build consensus, and promote timely, high-quality decision making without direct authority.
• Excellent communication, facilitation, problem-solving, analytical thinking, stakeholder management, and organizational skills.
• Ability to independently manage multiple priorities, objectives, timelines, and deadlines across programs or workstreams.
• Proficiency with planning tools such as Microsoft Project, or comparable project management software desired.
• Experience in AI tools use or implementation desired.
• PMP certification a plus but not required.
• Leadership Attributes: Collaborative team member who creates clarity, accountability, and alignment across diverse functional perspectives.
• Ability to connect program-level decisions to portfolio and company priorities.
• Pragmatic problem solver who anticipates challenges, frames options, and drives action.
• Credible partner who communicates with transparency and adapts effectively to different audiences, including senior leaders.
• Continuous-improvement mindset with a willingness to introduce and scale effective tools and practices.

The salary range for this position is $180,000 to $200,000 USD. Compensation will be determined based on several factors including, but not limited to; skill set, years of experience, and the employee’s geographic location. Please note that the required compensation details listed in US role postings reflect the base salary only, and do not include bonus, equity, or benefits unless otherwise provided.

Mirum Pharmaceuticals is committed to Equal Employment Opportunity (EEO) and to compliance with all Federal, State and Local laws that prohibit employment discrimination on the basis of race, age, national origin, ethnicity, religion, gender, gender identity, pregnancy, marital status, sexual orientation, citizenship, genetic disposition or characteristics, disability, veteran’s status or any other classification protected by applicable State/Federal/Local laws.

Mirum Pharmaceuticals provides reasonable accommodation for qualified individuals with disabilities and disabled veterans in job application procedures.